Angiotensin-kushandura enzyme inoshandura angiotensin-ini mune angiotensin II. Uye iyo yekupedzisira, sezvinozivikanwa, spasmodically inowedzera ropa mukati mevanhu. Izvi zvinoitwa nekuderedza midziyo, pamwe nekukandira aldosterone. Kuvhara angiotensin, ACE inhibitor inogona kupiwa.
Nokudaro, ACE inhibitor zvinodhaka zvipembenene zvinopesana nehutachiona zvakagamuchirwa zvakanaka kwemakore anopfuura makumi matatu pakuderedzwa kweropa. Kuti kuwedzere migumisiro ye inhibitor inorayirwa kutora pamwe chete ne diuretic.
Kurongwa kweACE inhibitors
Kana kusiyanisa mishonga, zvikamu zvakasiyana-siyana zvinoshandiswa. Nokudaro, maererano nehuwandu hwemagariro, mapoka aya emishonga anozivikanwa:
- Kuratidzwa kwenguva pfupi. Kubudirira kwemari iyi kunotora maawa anenge 5-6. Kana iwe usingatori mapiritsi anotevera panguva, zvinogona kunge zvakananga kumhanya mukumanikidza kumusoro. Dzinosanganisira, semuenzaniso, Captopril , iyo inofanira kutorwa kusvika katatu pazuva.
- Zvinoreva nehuwandu hunogara huripo. Zvinoshanda maawa gumi nemaviri. Ipa mishonga iyi kaviri pazuva - kazhinji mangwanani uye manheru. Mumiririri mukuru weboka iri remapiritsi-inhibitors yeACE - Enalapril .
- Mishonga yakawedzerwa migumisiro. Iyi mari inogamuchirwa nguva nenguva kamwe kamwe pazuva. Zvisinei, mumamiriro ezvinhu akaoma, kugamuchira nguva mbiri kunogonawo. Iri boka rinosanganisira Ramipril , Lisinopril nevamwe. Muboka rimwechete remishonga imomo iyo, iyo inogadziriswa ichichengeterwa kusvikira maawa 48 mushure mekupedzisira mapiritsi.
Kucherechedza ma pharmokinetic zvinhu, mapoka anotevera anosiyaniswa:
- mishonga iyo inoshandiswa inoshanda iripo;
- prodrugs.
Uyewo, ACE inhibitors yechizvarwa chitsva inorongerwa maererano nenzira inotevera yekugumisa:
- kubviswa neitsvo (yekutongwa kwe 70%);
- kunyunyuta kuburikidza nekuvhenekera uye cholagogic system;
- Kugadziriswa ne bile kuburikidza nehutachiona.
Kusiyanisa kwakadai kwemishonga kunonyanya kukosha nokuti chiremba anokwanisa kupa zvakakodzera zvakakodzera uyu murwere anobva pane zvinyorwa zvese zvezvipatara. Zvose zvakakosha zvegadziriro uye zvisikwa zvezvakaitika pane izvo zvipenyu zvinotorwa pano.
Migumisiro Yechiratidzo yeACE Inhibitors
Kunyange yakanakisisa ACE inhibitor inopa mimwe migumisiro yakaipa:
- kukoromora kukuru, kunokonzerwa nekuunganidza kwe bradykinin mumutambo wekupemha;
- hypotension ;
- general weak;
- kunyatsovira mumuromo;
- kuwedzera mu creatinine;
- Hyperkalemia, iyo yero iyo inowirirwa nekutora diuretics;
- kurwisa;
- kupera kwezvirwere zvakabatana, nezvimwewo.
Kuonekwa kwechimwe chezvinhu izvi zvinokonzerwa nemigumisiro ndicho chikonzero chekurumidza kutaura nechiremba achienda kunotora mumwe mushonga. Kana iwe ukasakanganwa mazamu akadai kana kuedza kusarudza mishonga iwe pachako, unogona kungowedzera mamiriro acho ezvinhu.
Contraindications kune kudya kweACE inhibitors
Pane huwandu hwemamiriro ezvinhu umo kushandiswa kweACE inhibitor mishonga inorambidzwa zvakasimba. Izvi zvinosanganisira:
- pamuviri;
- heart defects;
- stenosis yeriti inosvika kuitsvo;
- hyperkalemia;
- arthritis;
- lactation period;
- hypotension;
- kusawirirana nezvimwewo zvakadaro.
Muzvinhu zvose zviri pamusoro apa, kutungamirirwa kweACE inhibitor zvinodhaka kunongorongedzerwa chete kana mamwe maitiro asingabatsiri. Muchiitiko ichi, chiremba mushure mekunyatsorongororwa kwemurwere kunofanirwa kuyerwa pamusoro pezvinetso zvinogona kuitika uye zvibatsiro chaicho.