Thrombocytopenia inoshaya kana kuti yakadzika yeplateletlet (bloodlets). Aya masero eropa asingaoneki anokosha zvikuru pakuvhara ropa. Kutaura kuti thrombocytopenia inogona kuisa upenyu pangozi, nokuti inokonzera kubuda ropa uye kubuda kwemhepo kunhengo dzomukati.
Zvinokonzerwa nehutachiona hwehutachiona
Zvikonzero zve thrombocytopenia zvakasiyana kwazvo. Kushaya kweplatelet kunogona kuitika nekuda kwekudzivirira zvirwere zvekuchengetedzwa kwehutachiona nekuwedzerwa ropa, izvo zvisingaenderani nehutano hweboka, kana apo kune dzimwe nyika antigen inopinda mumuviri, somuenzaniso, hutachiona. Asi kazhinji kacho mumuviri womunhu, autoimmune thrombocytopenia inokura. Iyi ndiyo mamiriro ayo maitiro ezvirwere zvezvirwere zvezvirwere zvisingatauri "sa" platelet ine utano, iyo inotungamirira kukurudzirwa kwezvirwere kuti abvise "mutorwa". Kana iyo thrombocytopenia ichienda kune imwe zvirwere, zvino inonzi yechipiri. Zvinokonzera zvirwere zvakasiyana-siyana:
- collagenoses (dermatomyositis, systemic lupus erythematosus kana scleroderma );
- chronic and acute leukemia (Waldenstrom macroglobulinemia, myeloma);
- dzimwe zvirwere zvepfungwa uye chirwere chisingaperi chehepatitis.
Kana autoimmune thrombocytopenia ichizviratidza sechirwere chisina kurega, zvino inonzi chirwere cheVerlhof, uyewo inokosha kana idiopathic thrombocytopenia. Zvimwe zvinokonzera chirwere ichi hazvisi zvakanyatsosimbiswa. Pakati pezvinhu zvinotangira kukurudzirwa kwayo, kune hutachiona hwehutachiona uye hwebhakitiriya, maitiro ekuvhiya, zvirwere, kukuvadzwa uye kuiswa kwegamma globulin. Muchikamu makumi mashanu (45%) zvezviitiko, thrombocytopenia inokosha inoitika zvisingatauriki pasina chikonzero.
Zvinokonzera kugadzirwa kweprombocytopenia
Chirwere chinokonzera chibereko chinowanikwa mumuviri, apo marora emapfupa haagoni kuisa maplatelet mumutengo wavanenge uchida kuti uve mutambo wakakwana. Zvinokonzera iyi thrombocytopenia kuvanhu vakuru ndeizvi:
- aplastic anemia ;
- TAP-syndrome;
- myelodysplastic syndrome;
- myelosclerosis;
- metastases yemamwe maronda mumapfupa emapfupa;
- chiito chemakemikari (somuenzaniso, benzene).
Mukuwedzera, chibereko chinowedzera chinoratidzika sechikonzero chekukurumidza kweukemukari, apo kune tumarara yakadzika kuchinja kwehematopoiesis, nekudhakwa uye zvirwere zvakasiyana-siyana (viremia, miliary tuberculosis, bacteremia). Tambura kubva pakushayikwa kweplatelet nevaya vane uwandu hwevitamini B12 uye folic acid. Kubudirira kunogona kufambiswa kwetrombocytopenia uye kupesana nemishonga inonzi radiation kana kujekeswa nemirairo yeioni.
Zvinokonzera zvinodhaka zvepachirwere
Nezvinodhaka zvinokonzerwa nezvinodhaka, zvinokonzerwa nemasikirini anokonzerwa nemumwe mutorwa anorgen-mishonga inogadziriswa pamusoro peplatelets, kana kuti iyo antigenic yakarongwa yeplatelet inoshanduka. Muzviitiko zvakawanda, zvinokonzera rudzi urwu rwe thrombocytopenia zvinotevera zvinodhaka:
1. Zvinyorwa:
- Meprobamate;
- Phenobarbital;
- Sedormid;
- allyl isopropylbarbituric acid.
2. Alkaloids:
- Quinidine;
- Quinine.
- Antibiotics;
- Oxytetracycline;
- Streptomycin;
- Chloramphenicol;
- Ristocetin.
3. Antibacterial sulfonamides:
- Sulfidiazine;
- Sulfamethazine.
4. Mimwe mishonga:
- Dinitrophenol;
- iodide ye potassium;
- Digitoxin;
- Carbamazepine.
Zvinokonzera thrombocytopenia mune varwere veHIV
Thrombocytopenia inogona kuratidza vanhu vane HIV. Kune zvikonzero zviviri zvekugadzirisa chirwere ichi kune varwere:
- Kutanga, ndeyekuti HIV inotora megakaryocytes, zvichikonzera kushaya kweplatelet.
- Chechipiri, zvinodhaka zvinobatsira kurwisana nehutachiona zvinowanzovhiringidza marara matsvuku emunhu.