Igener's granulomatosis chirwere chinotarisa muviri chinoreva zvirwere zvakakomba uye zvinokurumidza kufambira mberi. Systemic vasculitis uye Wegener's granulomatosis inobatana zvikuru, nokuti zvirwere (antineutrophil cytoplasmic) zvinoumbwa mu granulomatosis, iyo inofanirwa neAIDSA-inosanganiswa nevasculitis.
Zvinokonzera Wegener's granulomatosis
Igener's granulomatosis inoreva kuzvipira, saka pane zvingava nemafuta. Ichokwadi, granulomatosis haina kukwana mumuviri wekudzivirira. Nokudaro, zviratidzo zvechirwere ndezvipembenene - HLA 〖B〗 _7, B_8, 〖DR〗 _2, 〖DQ〗 _w7.
Basa rezvirwere zvinotapurirwa rinowedzerwa neinorineutrophil cytoplasmic antibodies inobata neproteinase-3.
Wegener's granulomatosis - zviratidzo
Zviratidzo zvegranulomatosis kazhinji zvinowanzoitika pazera remakore makumi mana, asi hutachiwana hahuna basa.
Granulomatosis - kuputika kwemasvingo emidziyo miduku neya midzi: mawere, capillaries, arterioles uye arterioles. Mukugadziriswa kwehutano, nzvimbo yepamusoro yokufema, itsvo, meso, mapapu nedzimwe nhengo zvinosanganiswa.
Zviratidzo zvinotevera:
- kazhinji - kurasikirwa nekurema, kushaya simba, myalgia, arthralgia, fivha, mune zvisingawanzoitika, arthritis;
- nervous system - asymmetric polyneuropathy;
- maziso-ischemia emusana we optic, upofu, episcleritis ne-orbital granuloma uye exophthalmos;
- ganda - rashes necrotic elements;
- itsvo - glomerulonephritis , iyo inogona kutora nzira yekukurumidza;
- mapapu - zvipembenene zvinokura mu75% yevarwere nenzira yepiltrates, iyo inoumba matanda panguva yekuora; uye izvi zvinogona kuonekwa pleurisy, kukora.
- mapfupa emapfupa - anowanikwa mu 90% yevarwere nenzira ye rhinitis ne purulent-haemorrhagic secretion uye ulceration; kuperesa kweropa rinopinza kunokonzera kusungirirwa kwechisimba; Uyewo, chironda chinokanganisa marinha, nzeve, trachea, sinasal sinus, umo chironga chinoputika chinoonekwa.
Wegener's granulomatosis inewo maitiro maviri:
- inzvimbo - inosanganisa kunyanya nzira yekufema yepamusoro;
- huwandu - pamwe naye huri nhengo dzakawanda dzinokanganisa, uye izvi zvinopindirana nefivha, majoka-musungo kurwadziwa, kukwezva uye mwoyo kusakundikana.
Kuongororwa kweGenulomatosis Wegener
Izvi zvinoshandiswa neRheumatologist kubva pane zvakasiyana siyana:
- kuongorora ropa - biochemical uye general, iyo inogona kusimbisa granulomatosis, asi kubatsira kubvisa dzimwe zvirwere;
- urini kuongorora - inokwanisa kusimbisa kana kusabvisa kuora kwepvo (chimiro chechirwere chinosarudzika);
- X-ray ye sinasana yepasanasal uye thorax (computed tomography inopa mamwe mashoko akazara kupfuura aya akawanikwa ne X-ray);
- biopsy - iyo nzira chete inotsigira pachena kana inoramba kuvapo kwegranulomatosis; vanachiremba vanotora mhuka kubva mumhino kana mumhino, uye mune dzimwe nguva, itsvo nemapapu.
Mushonga we Wegener's granulomatosis
Kurapa kwechirwere ichi chinoitwa, kunyanya, nekubatanidzwa kwe corticosteroids uye cytostatics, izvo zvinoderedza basa
Nekukuvara kwetsvo kwakanyanya, mune dzimwe nguva, murwere anoda chirongwa chekugadzira.
Wegener's granulomatosis - kuraira
Kana kurapwa kusati kwatangwa panguva yakakodzera, ipapo kusagamuchirwa kwakashata kuchazadziswa mukati memwedzi 6-12, uye chiyero chekugara kweupenyu hachipfuuri mwedzi mitanhatu.
Muchiitiko chekurapa, kuregererwa kunopera anenge makore mana, mune dzimwe nguva makore gumi. Kurapa kwakakwana panguva ino yemazuva ekugadzirwa kwemishonga hazvibviri.