Fluoroquinolones inorwisa antimicrobial umo makemikari akaumbwa artificially. Kutanga kwekupinda muhupenyu hwedu, nenzira yechizvarwa chechipiri chezvinodhaka zveboka iri (ofloxacin, ciprofloxacin), inoonekwa semakore makumi masere ezana remakore rechi20. Zvimwe zvakasiyana-siyana zvaive zvikamu zvakakura zvikuru zvezviito mune zvekurwisana nemakemikari, mabhakitiriya, uyewo kukwirira kwakanyanya kwekunwa kwechirwere mumasero emuviri, uye kuchipararira kuva chechi yehutachiona.
Mumakore gumi, nyika yakaona fluoroquinolones III uye IV zvizvarwa, izvo zvaive zvakanyanya kuwanikwa maererano nekurwisa mabhakitiriya (kunyanya pneumococci), microorganisms, zvirwere zvepachigoni zvehutachiona hwemukati. Chimwe chezvakanaka zvechizvarwa chekupedzisira fluoroquinolones ndiyo kunyanya kushandiswa kwezvinhu.
Mishonga inorwisa mabhakitiriya eboka re fluoroquinolones, nekupinda zvakananga mumuviri, kuita nenzira iyo inodzivisa basa rinokosha reDNA-gyrase (iyo enzyme ye microbial cell, iyo inonyanya kukosha yehutachiona), iyo inouraya chipukanana.
Kubatana kwe fluoroquinolones
Fluoroquinolones dzine zviratidzo zvakakura zvekushandisa kwavo mune zvekurapa. Nekubatsira kwavo, zvinokurudzirwa kuita nhanho-ne-nhanho dzokurapa kwekurapa zvirwere zvakakomba, dzinobvumirana zvakanaka nedzimwe mishonga inorwisa mabhakitiriya.
Fluoroquinolones classification
- yekutanga-isiri-fluorinated finolones;
- yechipiri-gram-negative fluoroquinolones;
- yechitatu - kuporesa fluoroquinolones;
- yechina - kuporesa uye antianaerobic fluoroquinolones.
Fluoroquinolones yeichizvarwa chizvarwa chinoshandisa:
- nekuda kwezvirwere zvekufema uye zvirwere zvakasiyana-siyana zveET: maronchitis, pneumonia, sinusitis yakaoma, sinas frontal (uyewo zvinetso zvinoitika munguva yezvirwere zvemarudzi akasiyana-siyana);
- zvirwere zvinotapukira zvetsvo, pamwe chete ne genitourinary system: cystitis (yakaoma uye isingagumi), pyelonephritis (yakaoma, isingaperi, uye zvinetso zvinotangira munguva yechirwere ichi);
- ane zvirwere zvemuviri wepamuviri: dysentery, salmonellosis, zvirwere zvakabva pamatumbo emudumbu, typhoid fever;
- nekuda kwehutachiona hweganda uye articular system;
- ane zvirwere zvinoparadzirwa zvepabonde: gonorrhea, soft chancroid;
- nokuda kwokurapa nekudzivirira zvirwere zvakasiyana-siyana zvinotapukira, nehutachiona husina simba kana kukanganisa mabasa ayo;
- nokuda kwekuwanazve muviri mumuviri weperioperative.
Mishonga inorwisa mabhakitiriya ye fluoroquinolones mapundu emigumisiro:
- nokuda kwe hematopoietic system: kuperevedza ropa, kuperevedzwa kweeukocyte muropa (izvo zvinoita kuti kuderera kwezvidziviriro zvemuviri) uye platelets (iyo inowedzera ropa coagulability);
- nokuda kwemuviri wepamuviri: marwadzo mudumbu, flatulence, kuderedza kudya, kuonekwa kwekutsvaga, kusvibiswa kwesimbi mumuromo, muzviitiko zvisingawanzoitiki -
kuputika kwemukati; - nokuda kwechiropa: kuora kwekushanda kwayo;
- nokuda kwenheyo yenheyo: migraine, kusuruvara, kuzvidya mwoyo, kuzvidya mwoyo, kuonekwa kusingaoneki, muzviitiko zvisingawanzovi - kushaya simba, kupesana nemafungiro;
- kana paganda, pakanga pane pakarukwa pamuviri, pakanga pakaita sechitsva;
- nokuda kwekuvhenekera system: nephritis, kuchinja muvara wemuguta;
- nokuda kwemaitiro ematomical: mazamu ekuwedzera muvanhu;
- nokuda kwefupa nemasese matsuro: marwadzo.