Mukurapa kwemazuva ano uye pharmacology, zvimwe zviwanikwa zvinoitika nguva dzose. Zvose zvinoitwa kuti zvigadzirise kurapwa kweimwe zvirwere. Chimwe chezvinhu zvakanyanya kuvimbiswa ndezvokuti zvinokonzerwa ne monoclonal antibodies. Zvizhinji zvinorwisa zvirwere zvakabudiswa nemuviri zvinonzi polyclonal. Zvinyorwa zvese, zvakagadzirirwa kurwisana nemaantigen akasiyana, izvo zvinonyanya kuderedza kushanda kwekurapa. Monoclonal antibodies vanoita zvinangwa, vachibvumira kuti vagone kuwana zvakanakisisa zvinoguma zvakanaka.
Nheyo yekurapa ne monoclonal antibodies
Kusvika iye zvino, mishonga inonzi monoclonal inoshandiswa pakurongwa kana kunonzi inorapwa. Sezvo kuongororwa kwakaratidzwa, nzira iyi inoratidza mhinduro dzakanakisisa dzekurapa.
Monoclonal antibodies inorwisa zvirwere zvinotangira pane imwe foni yemagetsi. Ndiko kuti, vose vane imwe chete yakatangira sero. Monoclonal antibodies anoshandiswa ku:
- colitis ;
- rheumatoid arthritis;
- psoriasis;
- multiple sclerosis .
Vanobatsira kurwisana kunyange maitiro akaoma kwazvo e oncology.
Nheyo yekuita kweiyo monoclonal antibodies inonyoresa: vanoziva mamwe antigen uye vanobatanidza kwavari. Kuvonga izvi, maitiro ezvirwere zvemuviri anonyatsocherechedza dambudziko racho uye anotanga kurwisana naro. Ichokwadi, maitiro anonzi monoclonal antibodies anobvumira muviri kuti ubvise maantigen nemazvo. Rimwe ruzivo rwakakura rweMCA nderokuti dzinongobatsira maitiro ehutachiona akashandurwa pasina kukanganisa kune utano.
Monoclonal antibodies mu oncology
Kune varwere vakawanda vane incology, zvinodhaka zvinosanganisira monoclonal antibodies vave ndiyo tariro chete yekudzoka kune yakajairika. Chikamu chikuru chevarwere vane zviremara zvakakura zvinotyisa uye maitiro anonyadzisa mushure mokunge kurapwa kwave kunzwa kuregererwa kunooneka.
Kubatsirwa kweI ICA zvakajeka:
- Kusangana nekenza masero, monoclonal antibodies haisi kungoita kuti zviwedzere kuoneka, asiwo inowedzera. Uye neine ngozi dzinoshandiswa masero akachinja, muviri uri nyore kurwisana.
- Izvozvo zvinonzi monoclonal antibodies zvakawana chinangwa chazvo chinobatsira kudzivirira maitiro ekukura kwechirwere. Kuvonga uku kurapwa kwe oncology kunoshandiswa zvikuru.
- Zvirwere zvinoputika zvinowanikwa mu laboratori, uko zvakanyatsosanganiswa nekawandu rwema radioactive particles. Kudarika idzi zvikamu kuburikidza nemuviri, MCA inovanunura zvakananga kumarara, kwavanoita.
Kurapa kwekenza ne monoclonal antibodies kunogona kufananidzwa ne radiotherapy. Asi kusiyana nechekupedzisira, ICA inosimba. Chinangwa chavo chinoita kuti zvikwanise kushandisa nhamba shoma shoma ye radioactive particles.
Zvinodhaka zvinosanganisira monoclonal antibodies
Pasinei nokuti iyo ICA yakagadzirwa kwete kare kare, rutivi rwezvigadziro runevo rwakatotaridzika runoshamisa. Mishonga mitsva inoonekwa nguva dzose.
Iyo inonyanya kuzivikanwa nemasikirini emasokironi ayo anoshandiswa nhasi nokuda kwe psoriasis, multiple sclerosis, kenza, rheumatoid arthritis, urwere hunoita seizvi:
- Alemtuzumab;
- Alefacept;
- Daclusimab;
- Okrelizumab;
- Ustenkinumab;
- Basiliximab;
- Ofatumumab;
- Epratuzumab;
- Clenoliximab;
- Bevacizumab;
- Trastuzumab;
- Adalimumab;
- Enbrel;
- Infliximab nevamwe.
Zvechokwadi, mishonga ye monoclonal, semamwe akawanda emishonga, inogona kuva nemigumisiro. Kazhinji kacho, varwere mushure mekushandisa ICA vanonyunyuta nezvekuratidzwa kwezvinhu zvinokanganisika: kutengesa, kupera. Muzviitiko zvisingawanzoitiki, kurapwa kunoendeswa neyeusea, kurutsira, kana chirwere chemuviri.