Adrainolitics iboka remakemikari anorwisa mamwe adrenergic receptors. Zvichienderana nei adrenoreceptors inokanganiswa nezvinhu izvi, zvakakamurwa kuva beta uye alpha-blockers. Kugadzirira kunobva kwavari kunorayirirwa mukurwisana nemararamiro akasiyana-siyana emwoyo, maitiro epascular, kana zviitiko zvinokonzera kuparadzaniswa uye kuti kuve nekusimudzira kupikisa.
Kugadzirira Alpha-blockers
Iko kune mapoka maviri makuru emishonga.
Non-selective blockers
Zvinhu zvinodzvinyirira basa re postsynaptic adenoreceptors, zvichiita kuti kuwedzera kwechiedza chemidziyo uye donhi muzvinetso, uyewo kusunungurwa kwakanyanya kwe norepinephrine.
Mumiririri mukuru weboka rekutanga ndeye Fentolamine, iyo inobatsira kuwedzera midziyo yepakati pemvura. Apo chinhu icho chinotarisirwa mukati, chiitiko chinowanikwa mukati maminitsi gumi nemashanu.
Muchirapa, mushonga uyu ikozvino wakashandiswa kakawanda, asi unogona kurongerwa ku:
- kurara kana shribbite;
- kuongororwa kwepheochromocytoma;
- hypertensive crisis;
- hemorrhagic shock;
- Raynaud's disease .
Vamwe vamiririri veboka iri:
- Pyrroxane;
- Tropafen;
- Dihydroergotamine.
Selective Alpha-1-adrenoblockers
Izvo zvinhu zvinoratidzwa nebasa guru uye nguva. Ive nemigumisiro yakanaka pamwero weKolesterol muropa, nokudaro nokuderedza dambudziko rekuwedzera atherosclerosis. Mukuwedzera, izvo zvinhu hazvigadziri zvakagadzirwa nehuga, usawedzera kuwedzera uye kusiyanisa mune zvishoma zvigumisiro.
Kusarudza alpha-blockers kunosanganisira urongwa huwandu hwezvinodhaka:
- Doxazosin;
- Ter;
- Prazon.
Nokubudirira kwavo, mishonga iyi iri mberi kweFentolamine. Chinonyanya kukosha ndechokudzikisa kudzvinyirira kuburikidza nekuderedza kudzvinyirirwa kwemazwi emascula. Zvitoro zvinotanga kuratidzira mushure memaawa anenge mushure mekudya.
Zviratidzo zvekushandiswa kweAlfa-adrenoblockers
Funga nezvehutano hwehutano hwevamwe mapoka emishonga:
- Nehutachiona hwehutachiona hwehutachiona hwehutachiona (Raynaud's disease), mukurapa kwemazuva mazhinji ekuporesa maronda uye decubitus, uye mukutonga kwepheochromocytomas, Fentolamine neTropafen inorayirwa.
- Maitiro okutanga ekugadzirwa kweprotate adenoma inobatwa neprozazin, iyo inovandudza kubuda kwemuti.
- Alfa-1-adrenoblockers yainyanya kuwanika muhutachiona. Vanowedzera midziyo (kubva kuvaduku kusvika kune yakakura), nokudaro kuderedza kushandiswa. Kuderedza kudzvinyirira kunoita kuti kudonha kunokosha mumutoro payo myocardium, iyo inoita kuti mishonga iyi ibudirire mu myocardial infarction .
- Nokuda kwenguva refu, chirwere chinonzi Prazonin uye Doxazine chinoshandiswa.
- Fostopolitic dzimba dzakapiwa naFentolamin naPrazonin.
- Diabergergotamine inoshandiswa kwemigraine, pamwe chete nehuwandu uye huwandu hwemafunguro ehupenyu husina kukwana.
Contraindications Alpha-blockers
Usapa mishonga kune vanhu vane zvikanganiso zvinotevera:
- bradycardia;
- ane atherosclerosis;
- moyo palpitations;
- ane chirwere chetsvo;
- chinokonzerwa nehutano hwehutano, hunhu kune vakwegura vane chirwere cheshuga;
- chirwere cheIschemic kunze kwekufananidzwa kweeta-blockers;
- chirwere chekushandiswa kwemhepo.
Kurwisana kunopesana ndiko kuzvitakura.
Migumisiro isina kunaka inoratidzwa se:
- kudzvinyirirwa kunodonha;
- kutanga kwekudzimba;
- headaches;
- moyo wekushaya simba kushanda;
- tachycardia;
- vasodilation;
- kuzvimba kwemukasi membrane;
- nausea;
- kugona;
- kurwadziwa mumisungo.