Prokinetics mishonga iyo inhengo yeboka remakumbo motility stimulants. Chinhu chinonakidza chinobatana navo. Urongwa hwemishonga yeprokinetic, iyo inogona kuonekwa nevose gastroenterologists, haipo. Nyanzvi dzakasiyana dzakasiyana siyana dzinotsanangura urongwa hwakadaro. Chii chinonzi prokinetics?
Prokinetic antagonists ye dopamine receptors
Mhedzisiro yevanopikisa prokinetic inobva pakuti ivo vanokurumidza kusunga D2-dopamine receptors uye zvakanyanya kuderedza kupindura kwavo kune zviratidzo zvenyama zvemuviri womunhu. Vongai izvi vanobatsira kushandisa motokari basa remuviri, pamwe nekusimudzira antiemetic chiito. Kunyorwa kwemishonga yakadaro yeprokineti kunosanganisira:
- Bromopride;
- Domperidone;
- Metoclopramide;
- Dimetramipid.
Kazhinji kazhinji, dzose dzadzo dzinoshandiswa mukurapa gumbo rezvemimba Domperidone, pasinei nokuti ichokwadi sechirevo chechizvarwa chechipiri. Izvi zvinokonzerwa nekuti hazvina matambudziko makuru.
Dzimwe nyanzvi dzinotaura nezveboka iri revadzivisi uye Itopride. Asi zvepamutemo izvi hazvizivikanwi, sezvo zvine zvinopesana nehutachiona pane acetylcholine. Uyewo muboka iri reprokinetics iri kugadzirira zvezera reReflan neCerukal. Uye zvose nekuda kweshoko ravo rinoshanda ndiro metoclopramide. Mune zvimwe zviitiko, zvinogona kukonzera tachycardia, tinnitus, kugona uye chirwere.
Prokinetic antagonists anoshandiswa apo:
- achalasia of the esophagus ;
- chionda chemuviri kana duodenum;
- kupora kwemukati, izvo zvinoitika mushure mekushanda;
- flatulence;
- kurapwa kwegastroesophageal reflux chirwere;
- functional dyspepsia;
- kukanganiswa kukuru kwe bile ducts.
Muzviitiko zvisingawanzoitiki, zvinodhaka izvo zvikamu zveboka iri zvinogona kurongerwa nezvezvirwere zvepuro uye chiropa, kushambidzika uye kushungurudza kunokonzerwa nezvirwere zvinotapukira, kana kuti nehutachiona hwehutachiona. Inowanzoshandiswa kushandura kurutsa mushure mekupedzisira kana kuti zvidzidzo zvakasiyana-siyana zvemaharapa.
Prokinetics-stimulants yemukumbo peristalsis
Prokinetics inonyanyozivikanwa yeboka iri iri kugadzirira rine mazita aCoordax uye Mozapride. Izvo zvakafanana zvikuru munzira yekuita. Zvinopesana chete mukuti Mozapride haina zvisingabatsiri pane potassium channel basa, uye izvi zvinonyanya kuderedza dambudziko rekuvhiringidza kwepfungwa mukati.
Iri boka rinosanganisirawo madhiragi akadaro se:
- Aceclidine;
- Cerulety;
- Physiostigmine;
- Pyridostigmine bromide;
- Galantamine;
- Neostigmine monosulfate.
Prokinetics-agonist of motilin receptors
Zvirwere zvinonzi prokinetic zvinosanganisirawo zvinodhaka zvinosungirirwa kumaritine receptors (hormone inobatsira kuwedzera kukurira muchepasi esophageal sphincter, iyo inobatsira kubudisa). Izvi zvinosanganisira:
- Azithromycin;
- Clarithromycin;
- Atilmotine;
- Erythromycin.
Iyi mishonga inotungamirira kune zvakasimba zvakasimba zvepisistaltic contractions. Somugumisiro, dumbu rinosuka kubva mumvura kana mvura yakasimba. Uyewo, nguva yekufamba kwezvinhu zviri mumatumbo makuru zvakaderera zvakanyanya, kunyange mune zvimwe zvirwere, semuenzaniso, nechirwere cheshuga gastroparesis kana chinopfurikidza systemic scleroderma.
Kana iwe wakarayirwa prokinetic agonist ye-motilin receptor, chenjerera nokuti vane migumisiro yechirwere. Semuenzaniso, Erythromycin, inotorwa kwemwedzi inopfuura mwedzi, inogona kuwedzera njodzi yekufa nekuda kwekukuvara kwakanyanya kwemwoyo.