Bisphosphonate mazano

Chikoro chaidzo chemishonga chinodzivirira kurasikirwa kwetema uye kuparadzwa kwayo nemaosteoclasts inoshandiswa zvakasimba mukurapa kwehutachiona muvakadzi. Bisphosphonate kana dysphosphonate zvakagadzirwa zvinogadziriswa zvakaumbwa zvakangofanana nemaprophophosphates chaiwo asingagadzirwi nekugadzirisa. Nhasi ivo vanoonekwa semishonga chete ye osteoporosis nekubudirira kwakaratidzwa.

Mazita ekugadzirira boka reBasphosphonate

Mhando yemishonga inofungidzirwa inotsanangurwa mumapoka makuru maviri - madhiragi ane nitrogen nemishonga pasina iyo.

Mhando dzakasiyana dzinosanganisira:

1. Alendronic acid. Inonyatsokurudzira kudzorerwa kwegadziriro uye kuumbwa kwezvakananga histological sangano remapfupa, rinotarisa kutengesa uye resorption zvirongwa. Inowanzonyatsorongedzerwa senile uye pashure-menopausal osteoporosis, yakaipa hypercalcemia uye deforming osteitis, kudzivirira kuputika;
2. Zolendronate kana zoledronic acid. Kunoderedza basa reosteoclasts, asi haikanganisi maitiro epafu mineralization, ma mechanical properties uye mavara ekugadzira;
3. Clodronic acid (Clodron, Bonefos). Inoderedza ngozi yekuputsika kwemapfupa, inoita kuti munhu anetseke. Inoshandiswa mukurapa kwekuedza, kusarura kuparadza maitiro echirophege;
4. Bondronate (ibadronic acid). Yakagadzirirwa zvakananga kurapwa kwevakadzi, kunyanya kukosha munguva yekupedzisira. Yakashandiswawo panguva yehutori replacement therapy.

Bezazotistye bisphosphonates inogona kutorwa ne metastases mumapfupa, maitiro akaoma emuviri anouraya, hypercalcemia. Muchiitiko ichi, chisarudzo chakanaka ndicho chiyero chakakodzera, izvo chiremba anofanira kuverenga. Kana zvisina kudaro, zvikurukuru nekudarika, zvinetso zvingaitika.

Rwendo rwebhosphosphonate kugadzirira pasina nitrogen:

1. Tiludronate. Inowedzera huwandu hwemapfupa emapfupa, saka inowanzomirirwa muhupo hwekuora uye kuputsika;
2. Xidiphon, Pleistat kana sodium etidronate. Inonyanya kushandiswa muhutachiona hwakaoma hwePaget's disease, zvirwere zvehutachiona, hypercalcemia, yakanyanya osteoporosis;
3. Ibandronate sodium. Inobatsira zvakanaka nemishonga yemarmonal yekugadzirisa mishonga mu-post-menopausal period;
4. Clodronate. Inodzivisa kuparadzwa kwekristorium crystals, kukura kwe osteolysis. Mishonga iyi inorayirwa kune zviremara zvinokonzera matumbo, leukemias, lymphomas, metastases yakawanda.

Mirayiridzo ye bisphosphonates

Kubvuma kwemishonga inotsanangurwa pamusoro apa inoitwa maererano nezvinodiwa nachiremba 1 nguva pazuva.

Bisphosphonates haina kunyatsoputika, naizvozvo inofanira kushambidzwa nemvura yakanyorowa yakabikwa muchitonho chemazuva kuitira kuti inakire.

Izvo zvinodiwa kuchengeta kuputsa pakati pokugamuchirwa zvokudya uye mabhonphosphonate zvinodhaka. Matafura anofanira kutorwa 1,5 maawa asati adya pasimba risina chinhu - kwete pamberi pemaminitsi 60 mushure mekudya.

Chimwe chezvinhu zvisingafadzi zveboka iri rezvinodhaka ndiko kukwanisa kwavo kutsamwisa mucosa yechipupuriro, kukanganisa kuumbwa kwezvironda zviduku kumusoro. Saka, mushure mokutora bisphosphonates haugoni kurara pakarepo, zvinokosha pamaminitsi 90 (zvishoma) kuti uve panzvimbo yakarurama, iwe unogona kugara, asi zviri nani kufamba netsoka kana kungoita mabasa epamba. Izvi zvinogona kudzivirira migumisiro yakadaro semhepo yekutsvaira, kutsvaira reflux uye esophagitis.