Munguva pfupi yapfuura, kutarisirwa kwakanyanya kwakabhadharwa kune immunological murume kusununguka. Mushure mokunge uine hutsvakurudzo hwakawanda hwakava pachena kuti chikonzero cheizvi ma anti-antibodies antisperm, ayo akaumbwa nevarume mumatete uye maitiro avo. Asi chimwe chigumisiro chepermogram hachikwanise kujekesa zvachose chikonzero chekushaya vana. Nokudaro, kuitira kuti zviongororwe zvakajeka, vanachiremba vanopa mazano kune rumwe ruzivo rwemadzinza - MAR-test ("mixed agglutination reaction", iro rinoreva kuti "kusanganiswa kwegadziriro").
Antigens munyaya iyi ndeyemumakumbo mu spermatozoa. Kana vasingakwanisi kurarama neantisperm antibodies, ipapo spermatozoon yakafukidzwa nemumvuri untispermic inhibisa kufamba kwayo.
Iko-MAR-test inoita kuti zvive nyore kuona idzi antibodies kana kusimbisa kusavapo kwavo.
Izvo zvinowanzoitwa spermogram hazvibvumi kuti zviratidze chirwere ichi, sezvo muchirongwa ichi, spermatozoon, yakakanganiswa neAntisperm antibodies, inotaridzika yakakwana. Asi panguva imwe chete, haakwanisi kudiridza mazai uye chaizvoizvo haina kukwana. Iko-MAR-test inoita kuti zvive nyore kugona kuenzanisa kwepermatozoa yakakonzerwa nemasimba, kusvika kuwandu hwehuwandu hwakabudiswa mune imwe ejaculate. Uye chete ndiye anokwanisa kuratidza nhamba chaiyo yepermatozoa inobatsira iyo inokwanisa kutora chikamu pakugadzirwa kwehutano. Kana zvikamu zveMAR-kuedza kusina kunaka, izvo zvinoreva chiyero chinogamuchirwa chemasimba, ipapo zvimwe zvinokonzera kusabatwa mumarume zvinotsvakwa.
Zvimwe zvinokonzera kuonekwa kweAntisperm antibodies mumuviri wemurume
Zvechokwadi, zvikonzero nei muviri wemunhu unotanga kurwisana nemasero ake ane utano zvimwe:
- kugamuchirwa kwetraumas yezvikamu zvepabonde (kusanganisira kupindira kwokuvhiya);
- kukanganisa kwegadziro pakati pemidziyo yeropa nemigero yemasinal;
- kuvapo kwezvirwere;
- urogenital system chirwere;
- kune zvikonzero zvekusaziva kwakabva;
- kuita zvepabonde zvepabonde (kuvepo kukuru kwemapuroteni ekunze kunoonekwa nemuviri sekutyisidzira).
Zviratidzo zvechinangwa chekuedza MAR
Muedzo wokugadza kuvapo kana kusavapo kweantisperm antibodies inorondedzerwa kana pakaonekwa mu spermogram yezvirwere zvepermatozoa se:
- agglutination;
- aggregation;
- kuderedza kufamba;
- kusaramba kwenguva refu kwekudzivirira mumhuri yakaroorana;
- Kugadzirira kwaVIV uye ICSI .
Kana chiremba akaisa sarudzo iyi, zvingava zvakanaka kutora mararamiro emuMAR inyanzvi yepamusoro yezvokurapa, nokuti inonyanya kushandisa midziyo inoshandiswa mukugadzirisa kwemashoko ekuongororwa, izvo zvinoita kuti zvive nehutano hwekutsvakurudza zvakashata.
MAR-kuedzwa kweAntisperm antibodies inoratidza kuti vanoona kuti havasi kungoongorora muhombwe chete, asiwo mukuongorora sérum. Kugadziriswa kweM MAR-test:
- MAR-muedzo unowanzo - apo migumisiro yekuongororwa haina kuratidza spermatozoa yakakanganiswa neAntisperm antibodies.
- MAR-negative test rinoreva kuti chiyero che spermatozoa hachina kupfuura 50%. Ichi chiratidzo chinogonawo kuonekwa sechimiro.
- I-MAR-muedzo inofadza, inofungidzirwa apo kuongororwa kwakaratidza kuti muwandu we spermatozoa mune zvekare antispermic inopfuura 50%. Ichi chinoratidzira chinoratidza kuvepo kwehutachiona husina simba.
Kana mararamiro aM MAR akaratidza chibereko chakanaka che 100%, saka kubudiswa kwepanyama kubva kumunhu akaongororwa hakusi nyore. Muchiitiko ichi, vanachiremba vanotaura kushandisa maitiro ekutora ne IVF ne ICSI.