Zvirwere zvose zvekugadzirisa chirwere zvinosanganiswa nekudengenyeka kwemotokisi basa uye kubudiswa kwemabasa emukumbo muduku uye mukuru, mudumbu uye sophagus. Dambudziko iri rinonyanya kukosha nokuda kwebasa dyspepsia, biliary dyskinesia uye gastroesophageal reflux chirwere. Mukurapa kweiyo pathologies prokinetics yechizvarwa chitsva inoshandiswa - mishonga inobvumira kudzorera kugadzirisa kushanda kwebhuku repamuviri.
Modern prokinetics
Prokinetic properties dzinowanikwa nemakemikari akawanda, kusanganisira hormonal peptides, macrolide-type antibiotics uye vanopikisa opiate receptor. Asi isu tinofanira kusarudza zvinodhaka zvinoshandisa mabasa anotevera:
- kuwedzera mumutauro wechepasi esophageal sphincter;
- Kuvandudzwa kwekucheneswa kwemasimba;
- kuwedzera gastric motility;
- kuderera kwehuwandu hwekufungidzirwa kwemasimba uye nguva yekubatana kwemucosa wepopu uye zviri mukati memudumbu;
- kubviswa kwekunonoka kubudiswa kwezvokudya zvechingwa.
Nhasi, boka reprokinetic rinonyanya kushandiswa, rinokanganisa kushanda kwepamusoro chepachikamu chepamusoro:
- itopride;
- metoclopramide;
- cisapride;
- domperidone.
Ngationgororei pamusoro pezvo.
Ndezvipi zvinonzi prokinetics zviri nani?
Itopride kana itopride hydrochloride inhengo inoshanda inobereka miviri yakafanana pamwe chete:
- kuwedzera mukusunungurwa kweacetylcholine molecules;
- kukurudzira muscarinic receptors.
Kubatsira kwetiotropium inogadzirisa maitiro eesophageal sphincter, kuwedzera inzwi reguruvladder uye motokari inoshandiswa nemisungo yemukati uye musikana muduku. Nokudaro, zvinodhaka zvichibva pane izvo zvataurwa zvinogona kushandiswa mune chirwere chekutsamwisa kwemukumbo pamwe nekushanda dyspepsia nekudzivirira. Uyezve, chigadzirwa chacho chinonyanya kusimbisa kushandiswa kwepatendi mune imwe nhengo yemudumbu, inokurudzira kuparara kwemhepo inonzi reflux uye inogadzira antiemetic effect.
Prokinetics yerudzi rutsva pamusana we ticopride:
- Ganaton;
- Itomed;
- Primer.
Iyo inowanikwa mumapiritsi nemishonga inoshandiswa yakafanana ye 50 mg.
Mutsara unotevera wemishonga ndeye metoclopramide. Iri boka rezvinodhaka rine unhu hwakanaka kwazvo nekuda kwezviitiko zvakasiyana-siyana zveprokinetic zviri kuitwa, chimwe chazvo chiri kukurudzira zvakananga kwezvipfeko zvemitsipa inotapira yemudumbu.
Zvakakosha kuziva kuti metoclopramides inongororwa chete mumamiriro ezvinhu apo pfupi purogiramu yerapi inodiwa pamwe nekudiwa kwekuwana zvikwereti nekukurumidza. Izvi zvinokonzerwa nekuvapo kwenhamba huru yemigumisiro yakaipa. Pakati pevamiririri veboka iri tinocherechedza:
- Raglan;
- Wakachema.
Cisapride inofungidzirwa seimwe yemishonga inobatsira zvikuru yorudzi rwakatsanangurwa. Chinhu chavo chinonyanya kukosha ndechokushandiswa kwechimwe chitsva cheva serotonin receptors, iyo inowanikwa munzvimbo yeplexuses ye-neurons yemudumbu, esophagus uye mumatumbo. Mishonga yeboka iri inosanganisira:
- Coordination;
- Prepulsed.
Panguva imwecheteyo, cisaprial prokinetics mu mahwendefa anokonzera kukura kwezvinhu zvakakomba migumisiro kubva pamwoyo
Iyo inonyanya kuzivikanwa uye inodhura zvinodhaka zveboka rinotsanangurwa iro domperidone (Motilium). Kubudirira kwaro kurapa hakupfu kubudirira kwe metoclopramide, asi hazvikonzeri kuipa kwakaipa. Chimwe chete chinokonzerwa neMotilium chinoratidzirwa nedzidzo dzenguva refu dzekugamuchirwa nenzira yekuwedzera muzinga wehomoni prolactin.
The best prokinetic
Kufungisisa zvose zvakataurwa pamusoro apa-zvinotsanangurwa zvemazuva ano emishonga yeprokinetic, zvinogona kugumiswa kuti zvinonyanyogadzirwa nemishonga ndeye mari inobva kuitopride.