Chikonzero che tumor necrosis chinonzi extracellular multifunctional protein, inogadzirwa nema immunocompetent cells (macrophages, eosinophils). Nokuita pane mamwe masero emuviri, puroteni iyi inokonzera zvinotevera:
- kunonoka kwezvinokonzerwa nemasabolism;
- kuchinja muhupamhi hwemasvingo emidziyo yeropa;
- kuwedzera kwekugadzirwa kwemapleukin (1, 6, 8);
- kudzivirirwa kubva kumapachira emushonga;
- mutemo wekugadzira zvipembenene;
- antitumor effect.
Kuyera kweropa re tumor necrosis factor
Sezvo chirwere chinonzi necrosis chinotora chikamu munenge maitiro ose ezvirwere zvemuviri, kunyanya kwaro muropa kunotsanangurirwa nehukuru hwezvirwere zvinopisa. Kana kuongorora ropa kuchiratidza kuti tumarara necrosis chinokwidziridzwa, zvino izvi zvinogona kuratidza zvirwere zvakadai:
- zvirwere zvakanyanya zvinopararira (hepatitis C, utachiona hwehepes, endocarditis, nezvimwe);
- sepsis ;
- kushungurudzika kukuru;
- ischemic heart disease;
- psoriasis;
- zvirwere zvepachikafu;
- kupikisa kurambwa kwezviitiko zvakashandurwa;
- atherosclerosis yemarteri ye mwoyo uye uropi;
- chronic bronchopulmonary pathologies;
- autoimmune diseases ;
- zvirwere zvinokonzera zvirwere, nezvimwewo.
Iyo tumor necrosis chikonzero mune oncology
Kusarudza kuwanda kwemararamiro necrosis chinhu chakakosha pakucherechedza nzira yekenza. Nekuremekedza tumor cells, iyi protein inoratidza basa, iyo inoratidzirwa muhemorrhagic necrosis yezvinouraya neoplastic masero pasina kuparadza masero ane utano. Kubva pane chirwere chinonzi necrosis chinokonzerwa nenzira inokosha kubva kune ropa rinopa, zvinodhaka zvinokurudzirwa zvinogadziriswa zvinokonzerwa, izvo zvinenge zvisinganyanyi kutyisa muviri. Somuenzaniso, nerubatsiro rwechirwere Refnot chirwere chekenza yemazamu inoitwa.