Hypothiazide imishonga inenge iri yeboka rinoshandisa simba-thiazide diuretics . Mushonga unopiwa nenzira yehwendefa. Zvakare tichakurukura, kubva pakushandiswa kweHypothiazide mumapiritsi inogadzwa kana kusarudzwa, zvinopesana nei uye maitiro ekuparidzira.
Maitiro uye pharmacological action Hypothiazide
Icho chikuru chinoshandiswa pakugadzira Hypothiazide i hydrochlorothiazide. Sezvo rubatsiro rwekubatsira mukuumbwa kwemapiritsi zvinosanganiswa zvinhu zvakadai:
- talc;
- gelatin;
- magnesium stearate;
- starch;
- lactose monohydrate.
Hypothiazide inonzi diuretic iyo, pamwe nekuwedzera, inobata mishonga inopesana nehuwandu hwepamusoro wehutano hweropa. Nheyo yekurapa kwemahwendefa inobatanidza ne inhibitory effect ye hydrochlorothiazide pakushanda kwe epithelium ye renal tubules. Izvi zvinoratidzwa, zvikurukuru, mukuderedza kushandiswa kwemashure kwe sodium, chlorine (pamwe chete nekawandu ye potassium uye bicarbonates) uye kuenzana kwemaji emvura. Panewo kuderedzwa kwezvinyorwa zve uric acid uye calcium ions uye kuwedzera kwekuwedzerwa kwe-ion magnesium ions. Mishonga Hypothiazide inobatsira mune zvakasiyana-siyana zvinokonzerwa neyero-based base yemuviri - zvose ne acidification (acidosis) uye ne alkalization (alkalosis).
Nokuderedza huwandu hwe extracellular fluid inobudirira nokubvisa sodium, chlorine uye ion mvura, pamwe nekuwedzera maseroti maduku, chiito chekufungidzira chinoonekwa. Muchiitiko ichi, mushonga wacho hauna simba pamusana wehuwandu hwemhepo uye hausi kukonzera kuora mwoyo. Chiito chekufungidzira cheHypothiazide chinowedzera nechingwa chisina kudya. Uyezve, mushonga unobatsira kuderedza kushanda kwepisocular.
Nekushandisa kwenguva refu, chinhu chinoshanda chechirwere chinobatsira kunonoka kubuda kwe calcium ions neitsvo, iyo inogona kuva nemigumisiro yakanaka mukuvapo kweepi mabwe ane calcium salts.
Zviratidzo uye kupesana kwekushandiswa kweHypothiazide
Mahwendefa eHypothiazid anowanzotarisirwa kuti azvimba uye kubva kuwedzerwa kweropa. Maererano nemirayiridzo, izere rakazara rezviratidzo zvechirwere ichi ndeyotevera:
1. Arterial hypertension I and II stages (senzira ye monotherapy kana kusanganiswa nedzimwe nzira dzekusagadzirisa muviri).
2. Edema yakabva mumamiriro akasiyana-siyana, anosangana ne:
- nephrotic syndrome;
- chisingaperi chemwoyo kana renal kusakwana;
- premenstrual tension syndrome;
- chirwere chechiropa;
- acomerulonephritis;
- kugamuchirwa kwemahomoni, nezvimwewo.
3. Chidimbu chekudzivirira kuwedzerwa kwemvura yakakura (kunyanya muNephrogenic diabetes insipidus).
4. Chido chekudzivirira maumbirwo emabwe mumugwagwa wemuguta.
5. Glaucoma (mune zvakaoma kurapwa).
Contraindications kutora Hypothiazide:
- anuria;
- renal yakanyanya kana kusagadzikana kwehepatic;
- chirwere cheshuga mellitus muchiremera chakasimba;
- adrenocortical insufficiency;
- mimba (I trimester);
- refractory hypokalemia, hyponatremia, hypercalcemia;
- hypersensitivity kune zvikamu zvechirwere.
Nhamba yeHypothiazide
Muyero wechiremba unosarudzwa zvichienderana nehuwandu hwechirwere uye mararamiro ayo. Matafura anofanira kutorwa mushure mekudya.
Muzviitiko zvakawanda, nekuwedzera kwezvinetso, mishonga inotorwa pa 25-50 mg pazuva. Nhamba yemushonga we edematous syndrome inogona kuva 25-100 mg, uye Hypothiazide inotorwa kamwe chete pazuva kana rimwe zuva rimwe zuva. Mumamiriro ehutema eedema, chiyero chekutanga chemishonga chinogona kuwedzerwa kusvika 200 mg pazuva. Muchirwere chekutanga, sekutonga, tora mapiritsi makumi maviri nemashanu pazuva.